Citalopram vs Duloxetine

## Citalopram vs Duloxetine: Overview

This comparison examines the pharmacological differences between **Citalopram** and **Duloxetine**.

## Mechanism of Action

**Citalopram**: Selective serotonin reuptake inhibitor (SSRI); racemic mixture with escitalopram as active S-enantiomer.

**Duloxetine**: Serotonin-norepinephrine reuptake inhibitor (SNRI).

## Pharmacokinetics

**Half-life**: Citalopram — 35 hours; Duloxetine — 12 hours.

## Chemical Properties

**Molecular Formula**: Citalopram — C20H21FN2O; Duloxetine — C18H19NOS.

**Molecular Weight**: Citalopram — 324.3920 g/mol; Duloxetine — 297.4150 g/mol.

**Type**: Citalopram — Small molecule; Duloxetine — Small molecule.