Citalopram vs Duloxetine

Citalopram vs Duloxetine: Overview

This comparison examines the pharmacological differences between Citalopram and Duloxetine.

Mechanism of Action

Citalopram: Selective serotonin reuptake inhibitor (SSRI); racemic mixture with escitalopram as active S-enantiomer.

Duloxetine: Serotonin-norepinephrine reuptake inhibitor (SNRI).

Pharmacokinetics

Half-life: Citalopram — 35 hours; Duloxetine — 12 hours.

Chemical Properties

Molecular Formula: Citalopram — C20H21FN2O; Duloxetine — C18H19NOS.

Molecular Weight: Citalopram — 324.3920 g/mol; Duloxetine — 297.4150 g/mol.

Type: Citalopram — Small molecule; Duloxetine — Small molecule.