Diltiazem vs Hydrochlorothiazide

Diltiazem vs Hydrochlorothiazide: Overview

This comparison examines the pharmacological differences between Diltiazem and Hydrochlorothiazide.

Mechanism of Action

Diltiazem: Benzothiazepine calcium channel blocker.

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Pharmacokinetics

Half-life: Diltiazem — 3-4.5 hours; Hydrochlorothiazide — 6-15 hours.

Chemical Properties

Molecular Formula: Diltiazem — C22H26N2O4S; Hydrochlorothiazide — C7H8ClN3O4S2.

Molecular Weight: Diltiazem — 414.5190 g/mol; Hydrochlorothiazide — 297.7400 g/mol.

Type: Diltiazem — Small molecule; Hydrochlorothiazide — Small molecule.