Diphenhydramine vs Loratadine

Diphenhydramine vs Loratadine: Overview

This comparison examines the pharmacological differences between Diphenhydramine and Loratadine.

Mechanism of Action

Diphenhydramine: First-generation H1 antihistamine with anticholinergic properties.

Loratadine: Second-generation H1 antihistamine with minimal CNS effects.

Pharmacokinetics

Half-life: Diphenhydramine — 2-8 hours; Loratadine — 8 hours.

Chemical Properties

Molecular Formula: Diphenhydramine — C17H21NO; Loratadine — C22H23ClN2O2.

Molecular Weight: Diphenhydramine — 255.3550 g/mol; Loratadine — 382.8800 g/mol.

Type: Diphenhydramine — Small molecule; Loratadine — Small molecule.