Durvalumab vs Methylprednisolone

Durvalumab vs Methylprednisolone: Overview

This comparison examines the pharmacological differences between Durvalumab and Methylprednisolone.

Mechanism of Action

Durvalumab: Human IgG1 kappa anti-PD-L1 monoclonal antibody blocking PD-L1 binding to PD-1 and CD80.

Methylprednisolone: Intermediate-acting synthetic glucocorticoid.

Pharmacokinetics

Half-life: Durvalumab — 17 days; Methylprednisolone — 18-36 hours.

Chemical Properties

Molecular Formula: Methylprednisolone — C22H30O5.

Molecular Weight: Methylprednisolone — 374.4710 g/mol.

Type: Durvalumab — Antibody; Methylprednisolone — Small molecule.