Fluconazole vs Loratadine

## Fluconazole vs Loratadine: Overview

This comparison examines the pharmacological differences between **Fluconazole** and **Loratadine**.

## Mechanism of Action

**Fluconazole**: Inhibits fungal CYP51 (lanosterol 14-alpha-demethylase).

**Loratadine**: Second-generation H1 antihistamine with minimal CNS effects.

## Pharmacokinetics

**Half-life**: Fluconazole — 30 hours; Loratadine — 8 hours.

## Chemical Properties

**Molecular Formula**: Fluconazole — C13H12F2N6O; Loratadine — C22H23ClN2O2.

**Molecular Weight**: Fluconazole — 306.2710 g/mol; Loratadine — 382.8800 g/mol.

**Type**: Fluconazole — Small molecule; Loratadine — Small molecule.