Hydrochlorothiazide vs Irbesartan

Hydrochlorothiazide vs Irbesartan: Overview

This comparison examines the pharmacological differences between Hydrochlorothiazide and Irbesartan.

Mechanism of Action

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Irbesartan: Selective non-competitive angiotensin II type 1 receptor antagonist.

Pharmacokinetics

Half-life: Hydrochlorothiazide — 6-15 hours; Irbesartan — 11-15 hours.

Chemical Properties

Molecular Formula: Hydrochlorothiazide — C7H8ClN3O4S2; Irbesartan — C25H28N6O.

Molecular Weight: Hydrochlorothiazide — 297.7400 g/mol; Irbesartan — 428.5320 g/mol.

Type: Hydrochlorothiazide — Small molecule; Irbesartan — Small molecule.