Hydrochlorothiazide vs Lisinopril

## Hydrochlorothiazide vs Lisinopril: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Lisinopril**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Lisinopril**: ACE inhibitor preventing conversion of angiotensin I to angiotensin II.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Lisinopril — 12 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Lisinopril — C21H31N3O5.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Lisinopril — 405.4900 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Lisinopril — Small molecule.