Hydrochlorothiazide vs Metoprolol

Hydrochlorothiazide vs Metoprolol: Overview

This comparison examines the pharmacological differences between Hydrochlorothiazide and Metoprolol.

Mechanism of Action

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Metoprolol: Selective beta-1 adrenergic receptor blocker.

Pharmacokinetics

Half-life: Hydrochlorothiazide — 6-15 hours; Metoprolol — 3-7 hours.

Chemical Properties

Molecular Formula: Hydrochlorothiazide — C7H8ClN3O4S2; Metoprolol — C15H25NO3.

Molecular Weight: Hydrochlorothiazide — 297.7400 g/mol; Metoprolol — 267.3640 g/mol.

Type: Hydrochlorothiazide — Small molecule; Metoprolol — Small molecule.