Hydrochlorothiazide vs Sildenafil

Hydrochlorothiazide vs Sildenafil: Overview

This comparison examines the pharmacological differences between Hydrochlorothiazide and Sildenafil.

Mechanism of Action

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Sildenafil: Selective PDE5 inhibitor increasing cGMP.

Pharmacokinetics

Half-life: Hydrochlorothiazide — 6-15 hours; Sildenafil — 4 hours.

Chemical Properties

Molecular Formula: Hydrochlorothiazide — C7H8ClN3O4S2; Sildenafil — C22H30N6O4S.

Molecular Weight: Hydrochlorothiazide — 297.7400 g/mol; Sildenafil — 474.5800 g/mol.

Type: Hydrochlorothiazide — Small molecule; Sildenafil — Small molecule.