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Abametapir

CHEMBL2205807 Phase 4 Zugelassen Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
184.2 g/mol
LogP
2.2
Phase
4

Head lice and their eggs both depend on metalloproteinase enzymes for survival and hatching, and abametapir inhibits those enzymes. That dual activity is the practical advantage of the topical solution: a single application kills live lice and unhatched ova, so the nit-combing conventionally needed to remove viable eggs becomes unnecessary. The preparation is applied to the scalp and hair and acts locally at the site of application, with minimal systemic absorption, and it is approved for adults and children from six months of age. Targeting an enzyme class rather than the insect nervous system also separates it from the neurotoxic pediculicides. The compound is C12H12N2, roughly 184.2 g/mol.

A topical solution applied to the scalp and hair to treat head lice infestations in adults and children aged six months and older. It works by inhibiting enzymes that lice and their eggs need to survive, killing both live lice and unhatched eggs in a single application. The product is left on the hair for ten minutes and then rinsed off, with no nit-combing required afterward.

Molekularmasse

184,2400 g/mol

LogP

2,20

TPSA

25,80 Ų

Lipinski-Regel der Fünf

Bestanden

Therapeutische Bereiche

Dermatology

Wirkmechanismus

A metalloproteinase inhibitor. Abametapir inhibits louse metalloproteinases required for egg development and hatching, so ova exposed to it fail to produce viable nymphs.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanismus

A metalloproteinase inhibitor. Abametapir inhibits louse metalloproteinases required for egg development and hatching, so ova exposed to it fail to produce viable nymphs.

2D-Struktur

SVG PNG

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SMILES

                    
Cc1ccc(-c2ccc(C)cn2)nc1

                

                

                
                

                    
InChI

                    
InChI=1S/C12H12N2/c1-9-3-5-11(13-7-9)12-6-4-10(2)8-14-12/h3-8H,1-2H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C12H12N2

                    

                    
                    

                        
HBD / HBA

                        
- / 2

                    

                    
                    

                        
Rotierbare Bindungen

                        
1

                    

                    
                    
                    

                        
Schwere Atome

                        
14

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Häufig gestellte Fragen

                

                    
                    

                        
                        

                            
A topical solution applied to the scalp and hair to treat head lice infestations in adults and children aged six months and older. It works by inhibiting enzymes that lice and their eggs need to survive, killing both live lice and unhatched eggs in a single application. The product is left on the hair for ten minutes and then rinsed off, with no nit-combing required afterward.

                        

                    

                    

                    

                    
                    

                        
                        

                            
A metalloproteinase inhibitor. Abametapir inhibits louse metalloproteinases required for egg development and hatching, so ova exposed to it fail to produce viable nymphs.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Abametapir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2205807.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 15664.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-08-20.




        


        
        
    


    



    
Medizinischer Haftungsausschluss

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.