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Abametapir

CHEMBL2205807 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
184.2 g/mol
LogP
2.2
Phase
4

A topical solution applied to the scalp and hair to treat head lice infestations in adults and children aged six months and older. It works by inhibiting enzymes that lice and their eggs need to survive, killing both live lice and unhatched eggs in a single application. The product is left on the hair for ten minutes and then rinsed off, with no nit-combing required afterward.

Molecular Weight

184.2400 g/mol

LogP

2.20

TPSA

25.80 Ų

Lipinski RO5

Pass

Mechanism of Action

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanism

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
Cc1ccc(-c2ccc(C)cn2)nc1

                

                

                
                

                    
InChI

                    
InChI=1S/C12H12N2/c1-9-3-5-11(13-7-9)12-6-4-10(2)8-14-12/h3-8H,1-2H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C12H12N2

                    

                    
                    

                        
HBD / HBA

                        
- / 2

                    

                    
                    

                        
Rotatable Bonds

                        
1

                    

                    
                    
                    

                        
Heavy Atoms

                        
14

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
A topical solution applied to the scalp and hair to treat head lice infestations in adults and children aged six months and older. It works by inhibiting enzymes that lice and their eggs need to survive, killing both live lice and unhatched eggs in a single application. The product is left on the hair for ten minutes and then rinsed off, with no nit-combing required afterward.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Abametapir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2205807.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 15664.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.