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Acetazolamide Sodium

CHEMBL1200814 Phase 4 Zugelassen Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
244.2 g/mol
LogP
—
Phase
4

Parenteral administration is the reason the sodium salt of acetazolamide exists, supplying the same carbonic anhydrase inhibition when swallowing is not possible or when a faster onset is required. Situations calling for that route include acute glaucoma, raised intracranial pressure and selected states of fluid overload, all circumstances in which delay would matter. Sustained use carries the effects expected from the parent drug: urine output rises, and serum potassium may fall over a prolonged course. Choosing the injectable salt therefore changes the speed and route of delivery rather than the pharmacological target. The salt is recorded as C4H5N4NaO3S2 with a formula mass close to 244.2 g/mol.

The injectable sodium salt form of acetazolamide, used when oral administration is not possible or a faster onset of action is needed. It has the same carbonic anhydrase inhibiting properties as oral acetazolamide and is used in acute glaucoma, intracranial hypertension, and certain fluid-overload conditions. Like the oral form, it increases urine output and can lower potassium levels with prolonged use.

Molekularmasse

244,2000 g/mol

TPSA

127,00 Ų

Therapeutische Bereiche

Ophthalmology Glaucoma Hypertension

Wirkmechanismus

The injectable sodium salt acts by the same mechanism as oral acetazolamide: reversible inhibition of carbonic anhydrase, reducing aqueous humour formation in the eye and causing bicarbonate diuresis with a mild metabolic acidosis in the kidney.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanismus

The injectable sodium salt acts by the same mechanism as oral acetazolamide: reversible inhibition of carbonic anhydrase, reducing aqueous humour formation in the eye and causing bicarbonate diuresis with a …

2D-Struktur

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(=O)Nc1nnc(S([NH-])(=O)=O)s1.[Na+]

                

                

                
                

                    
InChI

                    
InChI=1S/C4H6N4O3S2.Na/c1-2(9)6-3-7-8-4(12-3)13(5,10)11;/h1H3,(H3,5,6,7,9,10,11);/q;+1/p-1

                

                

                

                    
                    

                        
Molecular Formula

                        
C4H5N4NaO3S2

                    

                    
                    

                        
HBD / HBA

                        
2 / 7

                    

                    
                    

                        
Rotierbare Bindungen

                        
2

                    

                    
                    
                    

                        
Schwere Atome

                        
14

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Häufig gestellte Fragen

                

                    
                    

                        
                        

                            
The injectable sodium salt form of acetazolamide, used when oral administration is not possible or a faster onset of action is needed. It has the same carbonic anhydrase inhibiting properties as oral acetazolamide and is used in acute glaucoma, intracranial hypertension, and certain fluid-overload conditions. Like the oral form, it increases urine output and can lower potassium levels with prolonged use.

                        

                    

                    

                    

                    
                    

                        
                        

                            
The injectable sodium salt acts by the same mechanism as oral acetazolamide: reversible inhibition of carbonic anhydrase, reducing aqueous humour formation in the eye and causing bicarbonate diuresis with a mild metabolic acidosis in the kidney.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Acetazolamide Sodium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1200814.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 13290219.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-08-20.




        


        
        
    


    



    
Medizinischer Haftungsausschluss

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.