Avapritinib

CHEMBL4204794 Phase 4 Zugelassen Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

498.6 g/mol

LogP

1.9

Phase

4

A potent and selective kinase inhibitor targeting KIT and PDGFRA mutations, used for unresectable or metastatic gastrointestinal stromal tumors. It offers a treatment option for a form of GIST that did not previously respond to available therapies.

Molekularmasse

498,6000 g/mol

LogP

1,90

TPSA

106,00 Å²

Lipinski-Regel der Fünf

Bestanden

Therapeutische Bereiche

Melanoma Breast Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D-Struktur

SVG PNG

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SMILES

Cn1cc(-c2cc3c(N4CCN(c5ncc([C@@](C)(N)c6ccc(F)cc6)cn5)CC4)ncnn3c2)cn1

InChI

InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35(8-10-36)24-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H,7-10,28H2,1-2H3/t26-/m0/s1

Molecular Formula

C26H27FN10

HBD / HBA

1 / 9

Rotierbare Bindungen

5

Schwere Atome

37

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Häufig gestellte Fragen

A potent and selective kinase inhibitor targeting KIT and PDGFRA mutations, used for unresectable or metastatic gastrointestinal stromal tumors. It offers a treatment option for a form of GIST that did not previously respond to available therapies.

Yes, Avapritinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4204794. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 118023034. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Struktur

Schnelldaten

Formel: C26H27FN10
Synonyme: 1

Externe Links

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Medizinischer Haftungsausschluss

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.