Avapritinib

CHEMBL4204794 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

498.6 g/mol

LogP

1.9

Phase

4

A potent and selective kinase inhibitor targeting KIT and PDGFRA mutations, used for unresectable or metastatic gastrointestinal stromal tumors. It offers a treatment option for a form of GIST that did not previously respond to available therapies.

Molecular Weight

498.6000 g/mol

LogP

1.90

TPSA

106.00 Å²

Lipinski RO5

Pass

Therapeutic Areas

Breast Cancer Colorectal Cancer Leukemia Melanoma

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

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SMILES

Cn1cc(-c2cc3c(N4CCN(c5ncc([C@@](C)(N)c6ccc(F)cc6)cn5)CC4)ncnn3c2)cn1

InChI

InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35(8-10-36)24-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H,7-10,28H2,1-2H3/t26-/m0/s1

Molecular Formula

C26H27FN10

HBD / HBA

1 / 9

Rotatable Bonds

5

Heavy Atoms

37

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

A potent and selective kinase inhibitor targeting KIT and PDGFRA mutations, used for unresectable or metastatic gastrointestinal stromal tumors. It offers a treatment option for a form of GIST that did not previously respond to available therapies.

Yes, Avapritinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4204794. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 118023034. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Quick Data

Formula: C26H27FN10
Synonyms: 1

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.