Clofarabine
A second-generation purine nucleoside analogue that interferes with DNA synthesis and repair, used to treat relapsed or refractory acute lymphoblastic leukemia in children. It inhibits both ribonucleotide reductase and DNA polymerase, triggering cancer cell death.
Molekularmasse
303,6800 g/mol
LogP
0,90
TPSA
119,00 Ų
Lipinski-Regel der Fünf
Bestanden
Therapeutische Bereiche
Wirkmechanismus
Functions as a nucleoside analog that is incorporated into viral or cellular DNA/RNA during replication, causing chain termination or coding errors that inhibit pathogen proliferation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Functions as a nucleoside analog that is incorporated into viral or cellular DNA/RNA during replication, causing chain termination or coding errors that inhibit pathogen proliferation.
2D-Struktur
Cite this structure
Embed this structure
SMILES
Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F
InChI
InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1
Molecular Formula
C10H11ClFN5O3
HBD / HBA
3 / 8
Rotierbare Bindungen
2
Schwere Atome
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
A second-generation purine nucleoside analogue that interferes with DNA synthesis and repair, used to treat relapsed or refractory acute lymphoblastic leukemia in children. It inhibits both ribonucleotide reductase and DNA polymerase, triggering cancer cell death.
Functions as a nucleoside analog that is incorporated into viral or cellular DNA/RNA during replication, causing chain termination or coding errors that inhibit pathogen proliferation.
Yes, Clofarabine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1750. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 119182. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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