Clofarabine
A second-generation purine nucleoside analogue that interferes with DNA synthesis and repair, used to treat relapsed or refractory acute lymphoblastic leukemia in children. It inhibits both ribonucleotide reductase and DNA polymerase, triggering cancer cell death.
分子量
303.6800 g/mol
LogP
0.90
TPSA
119.00 Ų
リピンスキーの五則
適合
治療領域
作用機序
Functions as a nucleoside analog that is incorporated into viral or cellular DNA/RNA during replication, causing chain termination or coding errors that inhibit pathogen proliferation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Functions as a nucleoside analog that is incorporated into viral or cellular DNA/RNA during replication, causing chain termination or coding errors that inhibit pathogen proliferation.
2D構造
Cite this structure
Embed this structure
SMILES
Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F
InChI
InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1
Molecular Formula
C10H11ClFN5O3
HBD / HBA
3 / 8
回転可能結合数
2
重原子数
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
A second-generation purine nucleoside analogue that interferes with DNA synthesis and repair, used to treat relapsed or refractory acute lymphoblastic leukemia in children. It inhibits both ribonucleotide reductase and DNA polymerase, triggering cancer cell death.
Functions as a nucleoside analog that is incorporated into viral or cellular DNA/RNA during replication, causing chain termination or coding errors that inhibit pathogen proliferation.
Yes, Clofarabine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1750. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 119182. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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