Demeclocycline
A tetracycline antibiotic with the additional property of blocking ADH (antidiuretic hormone) action in the kidney tubules, making it useful for treating the syndrome of inappropriate antidiuretic hormone secretion (SIADH). It is also used for bacterial infections.
Molekularmasse
464,9000 g/mol
LogP
0,70
TPSA
182,00 Ų
Lipinski-Regel der Fünf
Bestanden
Therapeutische Bereiche
Wirkmechanismus
Binds reversibly to the 30S ribosomal subunit, blocking the attachment of aminoacyl-tRNA to the ribosomal acceptor (A) site. This inhibits bacterial protein synthesis in a bacteriostatic manner.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds reversibly to the 30S ribosomal subunit, blocking the attachment of aminoacyl-tRNA to the ribosomal acceptor (A) site. This inhibits bacterial protein synthesis in a bacteriostatic manner.
2D-Struktur
Cite this structure
Embed this structure
SMILES
CN(C)[C@@H]1C(O)=C(C(N)=O)C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(O)ccc(Cl)c4[C@@H](O)[C@H]3C[C@@H]12
InChI
InChI=1S/C21H21ClN2O8/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31)/t6-,7-,14-,15-,21-/m0/s1
Molecular Formula
C21H21ClN2O8
HBD / HBA
6 / 9
Rotierbare Bindungen
2
Schwere Atome
32
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
A tetracycline antibiotic with the additional property of blocking ADH (antidiuretic hormone) action in the kidney tubules, making it useful for treating the syndrome of inappropriate antidiuretic hormone secretion (SIADH). It is also used for bacterial infections.
Binds reversibly to the 30S ribosomal subunit, blocking the attachment of aminoacyl-tRNA to the ribosomal acceptor (A) site. This inhibits bacterial protein synthesis in a bacteriostatic manner.
Yes, Demeclocycline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1591. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 54680690. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
Embed This Widget
Add the script tag and a data attribute to embed this widget.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<div data-drugfyi="drug" data-slug="demeclocycline"></div>Embed via iframe for maximum compatibility.
<iframe src="https://drugfyi.com/iframe/drug/demeclocycline/" width="420" height="400" frameborder="0" style="border:0;border-radius:10px;max-width:100%" loading="lazy"></iframe>Paste this URL in WordPress, Medium, or any oEmbed-compatible platform.
https://drugfyi.com/drug/demeclocycline/Add a dynamic SVG badge to your README or docs.
[](https://drugfyi.com/drug/demeclocycline/)Use the native HTML custom element.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<drugfyi-drug slug="demeclocycline"></drugfyi-drug>