Demeclocycline
A tetracycline antibiotic with the additional property of blocking ADH (antidiuretic hormone) action in the kidney tubules, making it useful for treating the syndrome of inappropriate antidiuretic hormone secretion (SIADH). It is also used for bacterial infections.
Masse moléculaire
464,9000 g/mol
LogP
0,70
TPSA
182,00 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Binds reversibly to the 30S ribosomal subunit, blocking the attachment of aminoacyl-tRNA to the ribosomal acceptor (A) site. This inhibits bacterial protein synthesis in a bacteriostatic manner.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds reversibly to the 30S ribosomal subunit, blocking the attachment of aminoacyl-tRNA to the ribosomal acceptor (A) site. This inhibits bacterial protein synthesis in a bacteriostatic manner.
Structure 2D
Cite this structure
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SMILES
CN(C)[C@@H]1C(O)=C(C(N)=O)C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(O)ccc(Cl)c4[C@@H](O)[C@H]3C[C@@H]12
InChI
InChI=1S/C21H21ClN2O8/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31)/t6-,7-,14-,15-,21-/m0/s1
Molecular Formula
C21H21ClN2O8
HBD / HBA
6 / 9
Liaisons Rotatives
2
Atomes Lourds
32
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A tetracycline antibiotic with the additional property of blocking ADH (antidiuretic hormone) action in the kidney tubules, making it useful for treating the syndrome of inappropriate antidiuretic hormone secretion (SIADH). It is also used for bacterial infections.
Binds reversibly to the 30S ribosomal subunit, blocking the attachment of aminoacyl-tRNA to the ribosomal acceptor (A) site. This inhibits bacterial protein synthesis in a bacteriostatic manner.
Yes, Demeclocycline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1591. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 54680690. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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