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Isocarboxazid

CHEMBL1201168 Phase 4 Zugelassen Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
231.2 g/mol
LogP
1.5
Phase
4

This monoamine oxidase inhibitor (MAOI) antidepressant works by blocking MAO enzymes that break down neurotransmitters including serotonin, norepinephrine, and dopamine, increasing their availability in the brain. It is used for depression that has not responded to other antidepressants. Strict dietary restrictions avoiding tyramine-rich foods are necessary to prevent dangerous hypertensive crises.

Molekularmasse

231,2500 g/mol

LogP

1,50

TPSA

67,20 Ų

Lipinski-Regel der Fünf

Bestanden

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D-Struktur

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Cc1cc(C(=O)NNCc2ccccc2)no1

                

                

                
                

                    
InChI

                    
InChI=1S/C12H13N3O2/c1-9-7-11(15-17-9)12(16)14-13-8-10-5-3-2-4-6-10/h2-7,13H,8H2,1H3,(H,14,16)

                

                

                

                    
                    

                        
Molecular Formula

                        
C12H13N3O2

                    

                    
                    

                        
HBD / HBA

                        
2 / 4

                    

                    
                    

                        
Rotierbare Bindungen

                        
4

                    

                    
                    
                    

                        
Schwere Atome

                        
17

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Häufig gestellte Fragen

                

                    
                    

                        
                        

                            
This monoamine oxidase inhibitor (MAOI) antidepressant works by blocking MAO enzymes that break down neurotransmitters including serotonin, norepinephrine, and dopamine, increasing their availability in the brain. It is used for depression that has not responded to other antidepressants. Strict dietary restrictions avoiding tyramine-rich foods are necessary to prevent dangerous hypertensive crises.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Isocarboxazid is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1201168.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 3759.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Medizinischer Haftungsausschluss

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.