Isocarboxazid

CHEMBL1201168 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

231.2 g/mol

LogP

1.5

Phase

4

This monoamine oxidase inhibitor (MAOI) antidepressant works by blocking MAO enzymes that break down neurotransmitters including serotonin, norepinephrine, and dopamine, increasing their availability in the brain. It is used for depression that has not responded to other antidepressants. Strict dietary restrictions avoiding tyramine-rich foods are necessary to prevent dangerous hypertensive crises.

Molecular Weight

231.2500 g/mol

LogP

1.50

TPSA

67.20 Å²

Lipinski RO5

Pass

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

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SMILES

Cc1cc(C(=O)NNCc2ccccc2)no1

InChI

InChI=1S/C12H13N3O2/c1-9-7-11(15-17-9)12(16)14-13-8-10-5-3-2-4-6-10/h2-7,13H,8H2,1H3,(H,14,16)

Molecular Formula

C12H13N3O2

HBD / HBA

2 / 4

Rotatable Bonds

4

Heavy Atoms

17

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

This monoamine oxidase inhibitor (MAOI) antidepressant works by blocking MAO enzymes that break down neurotransmitters including serotonin, norepinephrine, and dopamine, increasing their availability in the brain. It is used for depression that has not responded to other antidepressants. Strict dietary restrictions avoiding tyramine-rich foods are necessary to prevent dangerous hypertensive crises.

Yes, Isocarboxazid is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

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References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201168. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 3759. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Quick Data

Formula: C12H13N3O2
Synonyms: 1

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.