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Phenacetin

CHEMBL16073 Phase 4 Zugelassen Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
179.2 g/mol
LogP
1.6
Phase
4

Phenacetin is an analgesic and antipyretic drug of the anilide class that was historically used for pain relief and fever reduction, acting through its active metabolite acetaminophen to inhibit prostaglandin synthesis. It has been withdrawn from clinical use in most countries due to its association with analgesic nephropathy, hemolytic anemia, and carcinogenicity with chronic use.

Molekularmasse

179,2200 g/mol

LogP

1,60

TPSA

38,30 Ų

Lipinski-Regel der Fünf

Bestanden

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D-Struktur

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CCOc1ccc(NC(C)=O)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C10H13NO2/c1-3-13-10-6-4-9(5-7-10)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12)

                

                

                

                    
                    

                        
Molecular Formula

                        
C10H13NO2

                    

                    
                    

                        
HBD / HBA

                        
1 / 2

                    

                    
                    

                        
Rotierbare Bindungen

                        
3

                    

                    
                    
                    

                        
Schwere Atome

                        
13

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Häufig gestellte Fragen

                

                    
                    

                        
                        

                            
Phenacetin is an analgesic and antipyretic drug of the anilide class that was historically used for pain relief and fever reduction, acting through its active metabolite acetaminophen to inhibit prostaglandin synthesis. It has been withdrawn from clinical use in most countries due to its association with analgesic nephropathy, hemolytic anemia, and carcinogenicity with chronic use.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Phenacetin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL16073.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 4754.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medizinischer Haftungsausschluss

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.