Phenacetin

CHEMBL16073 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

179.2 g/mol

LogP

1.6

Phase

4

Phenacetin is an analgesic and antipyretic drug of the anilide class that was historically used for pain relief and fever reduction, acting through its active metabolite acetaminophen to inhibit prostaglandin synthesis. It has been withdrawn from clinical use in most countries due to its association with analgesic nephropathy, hemolytic anemia, and carcinogenicity with chronic use.

Molecular Weight

179.2200 g/mol

LogP

1.60

TPSA

38.30 Å²

Lipinski RO5

Pass

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

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SMILES

CCOc1ccc(NC(C)=O)cc1

InChI

InChI=1S/C10H13NO2/c1-3-13-10-6-4-9(5-7-10)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12)

Molecular Formula

C10H13NO2

HBD / HBA

1 / 2

Rotatable Bonds

3

Heavy Atoms

13

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

Phenacetin is an analgesic and antipyretic drug of the anilide class that was historically used for pain relief and fever reduction, acting through its active metabolite acetaminophen to inhibit prostaglandin synthesis. It has been withdrawn from clinical use in most countries due to its association with analgesic nephropathy, hemolytic anemia, and carcinogenicity with chronic use.

Yes, Phenacetin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL16073. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 4754. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Quick Data

Formula: C10H13NO2
Synonyms: 2

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.