Pramoxine
Pramoxine is a surface local anesthetic of the morpholine class that blocks voltage-gated sodium channels in sensory nerve terminals, preventing the initiation and propagation of nociceptive impulses to reduce pain and pruritus. It is used topically for the temporary relief of pain, itching, and discomfort associated with minor skin irritations, hemorrhoids, and anogenital conditions.
Molekularmasse
293,4000 g/mol
LogP
3,10
TPSA
30,90 Ų
Lipinski-Regel der Fünf
Bestanden
Wirkmechanismus
Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.
2D-Struktur
Cite this structure
Embed this structure
SMILES
CCCCOc1ccc(OCCCN2CCOCC2)cc1
InChI
InChI=1S/C17H27NO3/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18/h5-8H,2-4,9-15H2,1H3
Molecular Formula
C17H27NO3
HBD / HBA
- / 4
Rotierbare Bindungen
9
Schwere Atome
21
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
Pramoxine is a surface local anesthetic of the morpholine class that blocks voltage-gated sodium channels in sensory nerve terminals, preventing the initiation and propagation of nociceptive impulses to reduce pain and pruritus. It is used topically for the temporary relief of pain, itching, and discomfort associated with minor skin irritations, hemorrhoids, and anogenital conditions.
Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.
Yes, Pramoxine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1198. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 4886. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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