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Pramoxine

CHEMBL1198 Phase 4 Onaylandı Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
293.4 g/mol
LogP
3.1
Phase
4

Pramoxine is a surface local anesthetic of the morpholine class that blocks voltage-gated sodium channels in sensory nerve terminals, preventing the initiation and propagation of nociceptive impulses to reduce pain and pruritus. It is used topically for the temporary relief of pain, itching, and discomfort associated with minor skin irritations, hemorrhoids, and anogenital conditions.

Moleküler Ağırlık

293,4000 g/mol

LogP

3,10

TPSA

30,90 Ų

Lipinski RO5

Geçer

Etki Mekanizması

Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mekanizma

Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

2D Yapı

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CCCCOc1ccc(OCCCN2CCOCC2)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C17H27NO3/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18/h5-8H,2-4,9-15H2,1H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C17H27NO3

                    

                    
                    

                        
HBD / HBA

                        
- / 4

                    

                    
                    

                        
Döndürülebilir Bağlar

                        
9

                    

                    
                    
                    

                        
Ağır Atomlar

                        
21

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Sıkça Sorulan Sorular

                

                    
                    

                        
                        

                            
Pramoxine is a surface local anesthetic of the morpholine class that blocks voltage-gated sodium channels in sensory nerve terminals, preventing the initiation and propagation of nociceptive impulses to reduce pain and pruritus. It is used topically for the temporary relief of pain, itching, and discomfort associated with minor skin irritations, hemorrhoids, and anogenital conditions.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Pramoxine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1198.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 4886.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tıbbi Sorumluluk Reddi

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.