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Sildenafil Citrate

CHEMBL1737 Phase 4 Zugelassen Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
666.7 g/mol
LogP
—
Phase
4

A citrate salt form of sildenafil with the same therapeutic properties. Originally developed for heart conditions, this medication relaxes and widens blood vessels by blocking an enzyme called PDE5, increasing blood flow.

Molekularmasse

666,7000 g/mol

TPSA

250,00 Ų

Therapeutische Bereiche

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Benign Prostatic Hyperplasia Glaucoma Cardiovascular Disease Age-Related Macular Degeneration Respiratory Disease Non-Small Cell Lung Cancer Osteoporosis Chronic Obstructive Pulmonary Disease Parkinson's Disease Migraine Schizophrenia Systemic Lupus Erythematosus Multiple Sclerosis Non-Alcoholic Fatty Liver Disease Stroke Deep Vein Thrombosis / Pulmonary Embolism Obesity Type 2 Diabetes Hypertension Major Depressive Disorder Breast Cancer HIV/AIDS Hepatitis C Heart Failure Prostate Cancer Colorectal Cancer

Wirkmechanismus

Selective PDE5 inhibitor increasing cGMP.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanismus

Selective PDE5 inhibitor increasing cGMP.

2D-Struktur

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12.O=C(O)CC(O)(CC(=O)O)C(=O)O

                

                

                
                

                    
InChI

                    
InChI=1S/C22H30N6O4S.C6H8O7/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

                

                

                

                    
                    

                        
Molecular Formula

                        
C28H38N6O11S

                    

                    
                    

                        
HBD / HBA

                        
5 / 15

                    

                    
                    

                        
Rotierbare Bindungen

                        
12

                    

                    
                    
                    

                        
Schwere Atome

                        
46

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Häufig gestellte Fragen

                

                    
                    

                        
                        

                            
A citrate salt form of sildenafil with the same therapeutic properties. Originally developed for heart conditions, this medication relaxes and widens blood vessels by blocking an enzyme called PDE5, increasing blood flow.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Selective PDE5 inhibitor increasing cGMP.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Sildenafil Citrate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1737.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 135413523.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medizinischer Haftungsausschluss

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.