Tapinarof
Tapinarof is a first-in-class therapeutic aryl hydrocarbon receptor (AhR) agonist approved for the topical treatment of plaque psoriasis and atopic dermatitis in adults. By activating AhR, it normalizes skin barrier function, reduces pro-inflammatory cytokine production (including IL-17A, IL-22, and Th2 cytokines), and exerts antioxidant effects. Its non-steroidal mechanism offers an alternative to topical corticosteroids without the risk of skin atrophy.
Molekularmasse
254,3200 g/mol
LogP
4,60
TPSA
40,50 Ų
Lipinski-Regel der Fünf
Bestanden
Therapeutische Bereiche
Wirkmechanismus
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
2D-Struktur
Cite this structure
Embed this structure
SMILES
CC(C)c1c(O)cc(/C=C/c2ccccc2)cc1O
InChI
InChI=1S/C17H18O2/c1-12(2)17-15(18)10-14(11-16(17)19)9-8-13-6-4-3-5-7-13/h3-12,18-19H,1-2H3/b9-8+
Molecular Formula
C17H18O2
HBD / HBA
2 / 2
Rotierbare Bindungen
3
Schwere Atome
19
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
Tapinarof is a first-in-class therapeutic aryl hydrocarbon receptor (AhR) agonist approved for the topical treatment of plaque psoriasis and atopic dermatitis in adults. By activating AhR, it normalizes skin barrier function, reduces pro-inflammatory cytokine production (including IL-17A, IL-22, and Th2 cytokines), and exerts antioxidant effects. Its non-steroidal mechanism offers an alternative to topical corticosteroids without the risk of skin atrophy.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Tapinarof is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL259571. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6439522. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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