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Tapinarof

CHEMBL259571 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
254.3 g/mol
LogP
4.6
Phase
4

Tapinarof is a first-in-class therapeutic aryl hydrocarbon receptor (AhR) agonist approved for the topical treatment of plaque psoriasis and atopic dermatitis in adults. By activating AhR, it normalizes skin barrier function, reduces pro-inflammatory cytokine production (including IL-17A, IL-22, and Th2 cytokines), and exerts antioxidant effects. Its non-steroidal mechanism offers an alternative to topical corticosteroids without the risk of skin atrophy.

分子量

254.3200 g/mol

LogP

4.60

TPSA

40.50 Ų

Lipinski 五规则

符合

治疗领域

Psoriasis Systemic Lupus Erythematosus Atopic Dermatitis

作用机制

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

二维结构

SVG PNG

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SMILES

                    
CC(C)c1c(O)cc(/C=C/c2ccccc2)cc1O

                

                

                
                

                    
InChI

                    
InChI=1S/C17H18O2/c1-12(2)17-15(18)10-14(11-16(17)19)9-8-13-6-4-3-5-7-13/h3-12,18-19H,1-2H3/b9-8+

                

                

                

                    
                    

                        
Molecular Formula

                        
C17H18O2

                    

                    
                    

                        
HBD / HBA

                        
2 / 2

                    

                    
                    

                        
可旋转键数

                        
3

                    

                    
                    
                    

                        
重原子数

                        
19

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
Tapinarof is a first-in-class therapeutic aryl hydrocarbon receptor (AhR) agonist approved for the topical treatment of plaque psoriasis and atopic dermatitis in adults. By activating AhR, it normalizes skin barrier function, reduces pro-inflammatory cytokine production (including IL-17A, IL-22, and Th2 cytokines), and exerts antioxidant effects. Its non-steroidal mechanism offers an alternative to topical corticosteroids without the risk of skin atrophy.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Tapinarof is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL259571.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 6439522.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.