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Technetium Tc 99M Tetrofosmin

CHEMBL1200857 Phase 4 Zugelassen Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
899.8 g/mol
LogP
—
Phase
4

Technetium Tc 99m tetrofosmin is a lipophilic diphosphine radiopharmaceutical that accumulates in viable myocardium proportional to perfusion and mitochondrial membrane potential, used for myocardial perfusion SPECT imaging to evaluate coronary artery disease, assess myocardial viability, and risk-stratify patients with cardiovascular disease and hypertension. Its favorable dosimetry and imaging properties, with rapid blood clearance and low liver uptake, make it well-suited for same-day rest-stress protocols. It is one of the two most widely used myocardial perfusion agents alongside sestamibi.

Molekularmasse

899,8000 g/mol

TPSA

108,00 Ų

Therapeutische Bereiche

Cardiovascular Disease Hypertension

Wirkmechanismus

Contains a radioactive isotope that accumulates in specific tissues or organs, enabling detection and imaging of physiological processes or pathological conditions using nuclear medicine techniques.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanismus

Contains a radioactive isotope that accumulates in specific tissues or organs, enabling detection and imaging of physiological processes or pathological conditions using nuclear medicine techniques.

SMILES

CCOCC[PH+](CCOCC)CC[PH+](CCOCC)CCOCC.CCOCC[PH+](CCOCC)CC[PH+](CCOCC)CCOCC.O=[99Tc]=O

InChI

InChI=1S/2C18H40O4P2.2O.Tc/c2*1-5-19-9-13-23(14-10-20-6-2)17-18-24(15-11-21-7-3)16-12-22-8-4;;;/h2*5-18H2,1-4H3;;;/p+4/i;;;;1+1

Molecular Formula

C36H84O10P4Tc+4

HBD / HBA

- / 10

Rotierbare Bindungen

32

Schwere Atome

51

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Häufig gestellte Fragen

Technetium Tc 99m tetrofosmin is a lipophilic diphosphine radiopharmaceutical that accumulates in viable myocardium proportional to perfusion and mitochondrial membrane potential, used for myocardial perfusion SPECT imaging to evaluate coronary artery disease, assess myocardial viability, and risk-stratify patients with cardiovascular disease and hypertension. Its favorable dosimetry and imaging properties, with rapid blood clearance and low liver uptake, make it well-suited for same-day rest-stress protocols. It is one of the two most widely used myocardial perfusion agents alongside sestamibi.

Contains a radioactive isotope that accumulates in specific tissues or organs, enabling detection and imaging of physiological processes or pathological conditions using nuclear medicine techniques.

Yes, Technetium Tc 99M Tetrofosmin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

  • ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200857. Open-access bioactivity database.
  • PubChem — National Center for Biotechnology Information (NCBI). CID 6326947. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

Medizinischer Haftungsausschluss

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.