Technetium Tc 99M Tetrofosmin
Technetium Tc 99m tetrofosmin is a lipophilic diphosphine radiopharmaceutical that accumulates in viable myocardium proportional to perfusion and mitochondrial membrane potential, used for myocardial perfusion SPECT imaging to evaluate coronary artery disease, assess myocardial viability, and risk-stratify patients with cardiovascular disease and hypertension. Its favorable dosimetry and imaging properties, with rapid blood clearance and low liver uptake, make it well-suited for same-day rest-stress protocols. It is one of the two most widely used myocardial perfusion agents alongside sestamibi.
Moleküler Ağırlık
899,8000 g/mol
TPSA
108,00 Ų
Terapötik Alanlar
Etki Mekanizması
Contains a radioactive isotope that accumulates in specific tissues or organs, enabling detection and imaging of physiological processes or pathological conditions using nuclear medicine techniques.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Contains a radioactive isotope that accumulates in specific tissues or organs, enabling detection and imaging of physiological processes or pathological conditions using nuclear medicine techniques.
SMILES
CCOCC[PH+](CCOCC)CC[PH+](CCOCC)CCOCC.CCOCC[PH+](CCOCC)CC[PH+](CCOCC)CCOCC.O=[99Tc]=O
InChI
InChI=1S/2C18H40O4P2.2O.Tc/c2*1-5-19-9-13-23(14-10-20-6-2)17-18-24(15-11-21-7-3)16-12-22-8-4;;;/h2*5-18H2,1-4H3;;;/p+4/i;;;;1+1
Molecular Formula
C36H84O10P4Tc+4
HBD / HBA
- / 10
Döndürülebilir Bağlar
32
Ağır Atomlar
51
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
Technetium Tc 99m tetrofosmin is a lipophilic diphosphine radiopharmaceutical that accumulates in viable myocardium proportional to perfusion and mitochondrial membrane potential, used for myocardial perfusion SPECT imaging to evaluate coronary artery disease, assess myocardial viability, and risk-stratify patients with cardiovascular disease and hypertension. Its favorable dosimetry and imaging properties, with rapid blood clearance and low liver uptake, make it well-suited for same-day rest-stress protocols. It is one of the two most widely used myocardial perfusion agents alongside sestamibi.
Contains a radioactive isotope that accumulates in specific tissues or organs, enabling detection and imaging of physiological processes or pathological conditions using nuclear medicine techniques.
Yes, Technetium Tc 99M Tetrofosmin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200857. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6326947. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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