Thalidomide

CHEMBL468 Phase 4 Zugelassen Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

258.2 g/mol

LogP

0.3

Phase

4

This medication has a complex history — once withdrawn due to causing severe birth defects, it is now used under strict controls to treat multiple myeloma and a complication of leprosy called erythema nodosum leprosum. It works partly by modulating the immune system and blocking new blood vessel growth that tumors need to grow. It is available only through a special restricted program, and must never be taken during pregnancy.

Molekularmasse

258,2300 g/mol

LogP

0,30

TPSA

83,60 Å²

Lipinski-Regel der Fünf

Bestanden

Therapeutische Bereiche

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Endometriosis Pain Management Non-Small Cell Lung Cancer Alzheimer's Disease Epilepsy Melanoma Inflammatory Bowel Disease Psoriasis Systemic Lupus Erythematosus Chronic Kidney Disease Non-Alcoholic Fatty Liver Disease Lymphoma Hypertension Breast Cancer Chronic Pain Hepatitis C Tuberculosis Heart Failure Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D-Struktur

SVG PNG

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SMILES

O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1

InChI

InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)

Molecular Formula

C13H10N2O4

HBD / HBA

1 / 4

Rotierbare Bindungen

1

Schwere Atome

19

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Häufig gestellte Fragen

This medication has a complex history — once withdrawn due to causing severe birth defects, it is now used under strict controls to treat multiple myeloma and a complication of leprosy called erythema nodosum leprosum. It works partly by modulating the immune system and blocking new blood vessel growth that tumors need to grow. It is available only through a special restricted program, and must never be taken during pregnancy.

Yes, Thalidomide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL468. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5426. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Struktur

Schnelldaten

Formel: C13H10N2O4
Synonyme: 1

Externe Links

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Medizinischer Haftungsausschluss

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.