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Toloxatone

CHEMBL18116 Phase 4 Zugelassen Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
207.2 g/mol
LogP
1.2
Phase
4

Toloxatone is a selective and reversible monoamine oxidase A (MAO-A) inhibitor that prevents the oxidative deamination of serotonin and norepinephrine, increasing their synaptic concentrations and producing antidepressant effects. It is used for the treatment of depression and has the advantage over irreversible MAO inhibitors of lower risk for tyramine-induced hypertensive crisis (cheese effect) due to its reversibility and selectivity. Its RIMA (reversible inhibitor of MAO-A) profile allows competitive displacement by dietary tyramine, reducing the dietary restrictions required.

Molekularmasse

207,2300 g/mol

LogP

1,20

TPSA

49,80 Ų

Lipinski-Regel der Fünf

Bestanden

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D-Struktur

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Cc1cccc(N2CC(CO)OC2=O)c1

                

                

                
                

                    
InChI

                    
InChI=1S/C11H13NO3/c1-8-3-2-4-9(5-8)12-6-10(7-13)15-11(12)14/h2-5,10,13H,6-7H2,1H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C11H13NO3

                    

                    
                    

                        
HBD / HBA

                        
1 / 3

                    

                    
                    

                        
Rotierbare Bindungen

                        
2

                    

                    
                    
                    

                        
Schwere Atome

                        
15

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Häufig gestellte Fragen

                

                    
                    

                        
                        

                            
Toloxatone is a selective and reversible monoamine oxidase A (MAO-A) inhibitor that prevents the oxidative deamination of serotonin and norepinephrine, increasing their synaptic concentrations and producing antidepressant effects. It is used for the treatment of depression and has the advantage over irreversible MAO inhibitors of lower risk for tyramine-induced hypertensive crisis (cheese effect) due to its reversibility and selectivity. Its RIMA (reversible inhibitor of MAO-A) profile allows competitive displacement by dietary tyramine, reducing the dietary restrictions required.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Toloxatone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL18116.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 34521.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medizinischer Haftungsausschluss

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.