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Umbralisib Tosylate

CHEMBL3989869 Phase 4 Zugelassen Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
743.8 g/mol
LogP
—
Phase
4

Umbralisib tosylate is the tosylate salt form of umbralisib, a dual PI3K-delta and CK1-epsilon inhibitor used in treating relapsed or refractory B-cell lymphomas and leukemias. The tosylate salt was used in the clinical formulation to enhance chemical stability and oral bioavailability. Its clinical development was voluntarily withdrawn in the United States due to safety concerns identified in clinical trials.

Molekularmasse

743,8000 g/mol

TPSA

168,00 Ų

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D-Struktur

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(C)Oc1ccc(-c2nn([C@@H](C)c3oc4ccc(F)cc4c(=O)c3-c3cccc(F)c3)c3ncnc(N)c23)cc1F.Cc1ccc(S(=O)(=O)O)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C31H24F3N5O3.C7H8O3S/c1-15(2)41-24-9-7-18(12-22(24)34)27-26-30(35)36-14-37-31(26)39(38-27)16(3)29-25(17-5-4-6-19(32)11-17)28(40)21-13-20(33)8-10-23(21)42-29;1-6-2-4-7(5-3-6)11(8,9)10/h4-16H,1-3H3,(H2,35,36,37);2-5H,1H3,(H,8,9,10)/t16-;/m0./s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C38H32F3N5O6S

                    

                    
                    

                        
HBD / HBA

                        
2 / 13

                    

                    
                    

                        
Rotierbare Bindungen

                        
7

                    

                    
                    
                    

                        
Schwere Atome

                        
53

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Häufig gestellte Fragen

                

                    
                    

                        
                        

                            
Umbralisib tosylate is the tosylate salt form of umbralisib, a dual PI3K-delta and CK1-epsilon inhibitor used in treating relapsed or refractory B-cell lymphomas and leukemias. The tosylate salt was used in the clinical formulation to enhance chemical stability and oral bioavailability. Its clinical development was voluntarily withdrawn in the United States due to safety concerns identified in clinical trials.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Umbralisib Tosylate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL3989869.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 86707828.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medizinischer Haftungsausschluss

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.