Umbralisib Tosylate

CHEMBL3989869 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

743.8 g/mol

LogP

—

Phase

4

Umbralisib tosylate is the tosylate salt form of umbralisib, a dual PI3K-delta and CK1-epsilon inhibitor used in treating relapsed or refractory B-cell lymphomas and leukemias. The tosylate salt was used in the clinical formulation to enhance chemical stability and oral bioavailability. Its clinical development was voluntarily withdrawn in the United States due to safety concerns identified in clinical trials.

Masse moléculaire

743,8000 g/mol

TPSA

168,00 Å²

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

SVG PNG

Cite this structure

Embed this structure

SMILES

CC(C)Oc1ccc(-c2nn([C@@H](C)c3oc4ccc(F)cc4c(=O)c3-c3cccc(F)c3)c3ncnc(N)c23)cc1F.Cc1ccc(S(=O)(=O)O)cc1

InChI

InChI=1S/C31H24F3N5O3.C7H8O3S/c1-15(2)41-24-9-7-18(12-22(24)34)27-26-30(35)36-14-37-31(26)39(38-27)16(3)29-25(17-5-4-6-19(32)11-17)28(40)21-13-20(33)8-10-23(21)42-29;1-6-2-4-7(5-3-6)11(8,9)10/h4-16H,1-3H3,(H2,35,36,37);2-5H,1H3,(H,8,9,10)/t16-;/m0./s1

Molecular Formula

C38H32F3N5O6S

HBD / HBA

2 / 13

Liaisons Rotatives

7

Atomes Lourds

53

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

Umbralisib tosylate is the tosylate salt form of umbralisib, a dual PI3K-delta and CK1-epsilon inhibitor used in treating relapsed or refractory B-cell lymphomas and leukemias. The tosylate salt was used in the clinical formulation to enhance chemical stability and oral bioavailability. Its clinical development was voluntarily withdrawn in the United States due to safety concerns identified in clinical trials.

Yes, Umbralisib Tosylate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3989869. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 86707828. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

PillFYI

Vous cherchez des informations accessibles aux patients ?

Umbralisib Tosylate sur PillFYI

Structure

Données Clés

Formule: C38H32F3N5O6S

Liens externes

Cite

BibTeX, APA, MLA, Chicago, IEEE, Harvard

Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.