Metabolic Ratio (MR)
MRThe ratio of the concentration (or urinary excretion) of a parent drug to its metabolite, used as an index of metabolic enzyme activity. Metabolic ratios serve as phenotyping probes to identify poor, intermediate, extensive, and ultra-rapid metabolizers of CYP enzymes. They are measured in urine or plasma after administration of a probe substrate.
Beispiele
- Dextromethorphan/dextrorphan ratio for CYP2D6 phenotyping
- Omeprazole/5-hydroxyomeprazole ratio for CYP2C19 phenotyping
- Caffeine metabolic ratio (paraxanthine/caffeine) for CYP1A2 activity assessment
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The ratio of the concentration (or urinary excretion) of a parent drug to its metabolite, used as an index of metabolic enzyme activity. Metabolic ratios serve as phenotyping probes to …