Protease Inhibitor (PI)
PIA drug that inhibits protease enzymes responsible for cleaving peptide bonds in proteins. Protease inhibitors are critical in antiviral therapy, where they block viral polyprotein processing essential for viral maturation. They are designed to mimic the transition state of the proteolytic reaction for high-affinity binding.
Beispiele
- Ritonavir-boosted darunavir — HIV protease inhibitor
- Nirmatrelvir (in Paxlovid) — SARS-CoV-2 3CL protease inhibitor
- Bortezomib — proteasome inhibitor (multiple myeloma)
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A drug that inhibits protease enzymes responsible for cleaving peptide bonds in proteins. Protease inhibitors are critical in antiviral therapy, where they block viral polyprotein processing essential for viral maturation. …