Protein Binding
The reversible binding of drugs to plasma proteins (primarily albumin and alpha-1-acid glycoprotein). Only unbound (free) drug is pharmacologically active and available for distribution and elimination.
Beispiele
- Warfarin 99% bound
- Gentamicin <10% bound
- Displacement interactions (phenytoin + valproate)
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The reversible binding of drugs to plasma proteins (primarily albumin and alpha-1-acid glycoprotein). Only unbound (free) drug is pharmacologically active and available for distribution and elimination.