Volume of Distribution (Vd)
VdA proportionality constant relating total amount of drug in the body to plasma concentration. A large Vd indicates extensive tissue distribution. Does not correspond to a real physiological volume.
Beispiele
- Warfarin Vd ~8L (plasma-bound)
- Chloroquine Vd ~200L/kg (tissue-bound)
- Digoxin Vd ~500L
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A proportionality constant relating total amount of drug in the body to plasma concentration. A large Vd indicates extensive tissue distribution. Does not correspond to a real physiological volume.