Major
Established
Beschreibung
Co-prescribing two SSRIs leads to additive serotonin excess with no therapeutic benefit and high risk of serotonin syndrome.
Mechanismus
Both escitalopram and sertraline inhibit the serotonin transporter (SERT); concurrent use causes additive blockade and serotonin accumulation.
Klinische Bedeutung
Combination offers no evidence-based advantage and increases serotonin toxicity risk significantly.
Maßnahmen
Contraindicated; switch fully from one SSRI to another with appropriate washout period rather than combining.
Medizinischer Haftungsausschluss
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