Beschreibung
Ibuprofen combined with SSRIs markedly increases the risk of GI bleeding through synergistic impairment of platelet function and gastric mucosal defense.
Mechanismus
SSRIs deplete serotonin in platelets, reducing aggregation; ibuprofen inhibits COX-1–mediated thromboxane A2 synthesis and damages gastric mucosa. Both effects converge to heighten GI hemorrhage risk.
Klinische Bedeutung
Epidemiological data show a 15-fold increase in upper GI bleed risk with NSAID + SSRI, compared with a 3-fold increase for each alone.
Maßnahmen
Avoid combination if possible; if co-administration is necessary, add a PPI and use the lowest NSAID dose for the shortest duration.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.