Description

Ibuprofen combined with SSRIs markedly increases the risk of GI bleeding through synergistic impairment of platelet function and gastric mucosal defense.

Mécanisme

SSRIs deplete serotonin in platelets, reducing aggregation; ibuprofen inhibits COX-1–mediated thromboxane A2 synthesis and damages gastric mucosa. Both effects converge to heighten GI hemorrhage risk.

Signification clinique

Epidemiological data show a 15-fold increase in upper GI bleed risk with NSAID + SSRI, compared with a 3-fold increase for each alone.

Prise en charge

Avoid combination if possible; if co-administration is necessary, add a PPI and use the lowest NSAID dose for the shortest duration.

Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.