Acetylcysteine Lysine
A salt form of acetylcysteine combined with the amino acid lysine, used in some countries as an inhaled or injected mucolytic agent to reduce the thickness and stickiness of mucus in the airways. It works in the same way as acetylcysteine by breaking apart the chemical bonds that make mucus viscous, making it easier to cough up. This formulation may be preferred in certain clinical settings for its improved tolerability profile.
Molecular Weight
309.3900 g/mol
TPSA
157.00 Ų
Mechanism of Action
Breaks disulfide bonds in mucus glycoproteins, reducing mucus viscosity and facilitating clearance from the airways.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Breaks disulfide bonds in mucus glycoproteins, reducing mucus viscosity and facilitating clearance from the airways.
2D Structure
Cite this structure
Embed this structure
SMILES
CC(=O)N[C@@H](CS)C(=O)O.NCCCC[C@H](N)C(=O)O
InChI
InChI=1S/C6H14N2O2.C5H9NO3S/c7-4-2-1-3-5(8)6(9)10;1-3(7)6-4(2-10)5(8)9/h5H,1-4,7-8H2,(H,9,10);4,10H,2H2,1H3,(H,6,7)(H,8,9)/t5-;4-/m00/s1
Molecular Formula
C11H23N3O5S
HBD / HBA
6 / 8
Rotatable Bonds
8
Heavy Atoms
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
A salt form of acetylcysteine combined with the amino acid lysine, used in some countries as an inhaled or injected mucolytic agent to reduce the thickness and stickiness of mucus in the airways. It works in the same way as acetylcysteine by breaking apart the chemical bonds that make mucus viscous, making it easier to cough up. This formulation may be preferred in certain clinical settings for its improved tolerability profile.
Breaks disulfide bonds in mucus glycoproteins, reducing mucus viscosity and facilitating clearance from the airways.
Yes, Acetylcysteine Lysine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL6068327. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 9883132. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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