Acrivastine
A short-acting antihistamine that relieves allergy symptoms such as sneezing, runny nose, and itchy eyes by blocking histamine receptors involved in allergic reactions. It is less sedating than older antihistamines and is often combined with a decongestant to treat nasal congestion alongside allergy symptoms. It requires dosing three times daily due to its relatively brief duration of action.
Molecular Weight
348.4000 g/mol
LogP
1.60
TPSA
53.40 Ų
Lipinski RO5
Pass
Mechanism of Action
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
2D Structure
Cite this structure
Embed this structure
SMILES
Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1
InChI
InChI=1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+
Molecular Formula
C22H24N2O2
HBD / HBA
1 / 4
Rotatable Bonds
6
Heavy Atoms
26
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
A short-acting antihistamine that relieves allergy symptoms such as sneezing, runny nose, and itchy eyes by blocking histamine receptors involved in allergic reactions. It is less sedating than older antihistamines and is often combined with a decongestant to treat nasal congestion alongside allergy symptoms. It requires dosing three times daily due to its relatively brief duration of action.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Acrivastine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1224. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5284514. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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