Alatrofloxacin
A prodrug fluoroquinolone antibiotic that is converted in the body to trovafloxacin, a broad-spectrum antibacterial agent effective against a wide range of bacterial infections. It works by inhibiting bacterial DNA replication enzymes, preventing bacteria from reproducing and allowing the immune system to clear the infection.
Molecular Weight
558.5000 g/mol
LogP
-0.20
TPSA
158.00 Ų
Lipinski RO5
Fail
Mechanism of Action
Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This leads to breakage of bacterial chromosomal DNA and rapid cell death.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This leads to breakage of bacterial chromosomal DNA and rapid cell death.
2D Structure
Cite this structure
Embed this structure
SMILES
C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H]1[C@@H]2CN(c3nc4c(cc3F)c(=O)c(C(=O)O)cn4-c3ccc(F)cc3F)C[C@@H]21
InChI
InChI=1S/C26H25F3N6O5/c1-10(30)24(37)31-11(2)25(38)32-20-14-7-34(8-15(14)20)23-18(29)6-13-21(36)16(26(39)40)9-35(22(13)33-23)19-4-3-12(27)5-17(19)28/h3-6,9-11,14-15,20H,7-8,30H2,1-2H3,(H,31,37)(H,32,38)(H,39,40)/t10-,11-,14-,15+,20+/m0/s1
Molecular Formula
C26H25F3N6O5
HBD / HBA
4 / 12
Rotatable Bonds
7
Heavy Atoms
40
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
A prodrug fluoroquinolone antibiotic that is converted in the body to trovafloxacin, a broad-spectrum antibacterial agent effective against a wide range of bacterial infections. It works by inhibiting bacterial DNA replication enzymes, preventing bacteria from reproducing and allowing the immune system to clear the infection.
Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This leads to breakage of bacterial chromosomal DNA and rapid cell death.
Yes, Alatrofloxacin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201197. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3086677. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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