Alectinib

CHEMBL1738797 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

482.6 g/mol

LogP

5.2

Phase

4

A targeted therapy that selectively blocks an abnormal protein called ALK that drives the growth of certain cancers, particularly non-small cell lung cancer with ALK gene rearrangements. By precisely inhibiting this signaling pathway, alectinib helps stop tumor growth and has good penetration into the brain, making it effective against cancer that has spread there.

Molecular Weight

482.6000 g/mol

LogP

5.20

TPSA

72.40 Å²

Lipinski RO5

Pass

Therapeutic Areas

Bladder Cancer Breast Cancer Colorectal Cancer Lymphoma Melanoma Non-Small Cell Lung Cancer Ovarian Cancer Pancreatic Cancer Prostate Cancer Thyroid Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

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SMILES

CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O

InChI

InChI=1S/C30H34N4O2/c1-4-20-16-23-24(17-26(20)34-9-7-21(8-10-34)33-11-13-36-14-12-33)30(2,3)29-27(28(23)35)22-6-5-19(18-31)15-25(22)32-29/h5-6,15-17,21,32H,4,7-14H2,1-3H3

Molecular Formula

C30H34N4O2

HBD / HBA

1 / 5

Rotatable Bonds

3

Heavy Atoms

36

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

A targeted therapy that selectively blocks an abnormal protein called ALK that drives the growth of certain cancers, particularly non-small cell lung cancer with ALK gene rearrangements. By precisely inhibiting this signaling pathway, alectinib helps stop tumor growth and has good penetration into the brain, making it effective against cancer that has spread there.

Yes, Alectinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1738797. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 49806720. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Quick Data

Formula: C30H34N4O2
Synonyms: 1

External Links

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.