Alfentanil Hydrochloride

CHEMBL1200531 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

453.0 g/mol

LogP

—

Phase

4

The hydrochloride salt of alfentanil, an ultra-short-acting synthetic opioid used intravenously during anesthesia to provide analgesia and reduce the amount of other anesthetic medications needed. Its rapid onset and brief duration of action make it particularly valuable for short surgical procedures and procedural sedation.

Molecular Weight

453.0000 g/mol

TPSA

81.10 Å²

Therapeutic Areas

Bipolar Disorder Bladder Cancer Breast Cancer Chronic Kidney Disease Chronic Pain Colorectal Cancer Epilepsy Generalized Anxiety Disorder Heart Failure Hypertension Insomnia Migraine Non-Small Cell Lung Cancer Ovarian Cancer Pain Management Pancreatic Cancer Prostate Cancer Schizophrenia Thyroid Cancer

Mechanism of Action

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanism

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission …

2D Structure

SVG PNG

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SMILES

CCC(=O)N(c1ccccc1)C1(COC)CCN(CCn2nnn(CC)c2=O)CC1.Cl

InChI

InChI=1S/C21H32N6O3.ClH/c1-4-19(28)27(18-9-7-6-8-10-18)21(17-30-3)11-13-24(14-12-21)15-16-26-20(29)25(5-2)22-23-26;/h6-10H,4-5,11-17H2,1-3H3;1H

Molecular Formula

C21H33ClN6O3

HBD / HBA

1 / 6

Rotatable Bonds

9

Heavy Atoms

31

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

The hydrochloride salt of alfentanil, an ultra-short-acting synthetic opioid used intravenously during anesthesia to provide analgesia and reduce the amount of other anesthetic medications needed. Its rapid onset and brief duration of action make it particularly valuable for short surgical procedures and procedural sedation.

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.

Yes, Alfentanil Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200531. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 64761. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Quick Data

Formula: C21H33ClN6O3
Synonyms: 1

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.