Ambenonium
A long-acting cholinesterase inhibitor that prevents the breakdown of acetylcholine at the neuromuscular junction, used to treat myasthenia gravis, an autoimmune disease causing muscle weakness. By maintaining higher levels of acetylcholine at nerve-muscle connections, it improves muscle strength and endurance in affected individuals.
Molecular Weight
537.6000 g/mol
LogP
5.10
TPSA
58.20 Ų
Lipinski RO5
Fail
Mechanism of Action
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
2D Structure
Cite this structure
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SMILES
CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)Cc1ccccc1Cl)Cc1ccccc1Cl
InChI
InChI=1S/C28H40Cl2N4O2/c1-5-33(6-2,21-23-13-9-11-15-25(23)29)19-17-31-27(35)28(36)32-18-20-34(7-3,8-4)22-24-14-10-12-16-26(24)30/h9-16H,5-8,17-22H2,1-4H3/p+2
Molecular Formula
C28H42Cl2N4O2+2
HBD / HBA
2 / 2
Rotatable Bonds
14
Heavy Atoms
36
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
A long-acting cholinesterase inhibitor that prevents the breakdown of acetylcholine at the neuromuscular junction, used to treat myasthenia gravis, an autoimmune disease causing muscle weakness. By maintaining higher levels of acetylcholine at nerve-muscle connections, it improves muscle strength and endurance in affected individuals.
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
Yes, Ambenonium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1652. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2131. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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