Amcinonide
A high-potency topical corticosteroid that reduces skin inflammation, redness, and itching by suppressing immune mediators and stabilizing cell membranes in the skin. It is used for inflammatory skin conditions such as psoriasis, eczema, and contact dermatitis that have not responded adequately to lower-potency steroids.
Molecular Weight
502.6000 g/mol
LogP
3.60
TPSA
99.10 Ų
Lipinski RO5
Pass
Mechanism of Action
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
2D Structure
Cite this structure
Embed this structure
SMILES
CC(=O)OCC(=O)[C@@]12OC3(CCCC3)O[C@@H]1C[C@H]1[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]12C
InChI
InChI=1S/C28H35FO7/c1-16(30)34-15-22(33)28-23(35-26(36-28)9-4-5-10-26)13-20-19-7-6-17-12-18(31)8-11-24(17,2)27(19,29)21(32)14-25(20,28)3/h8,11-12,19-21,23,32H,4-7,9-10,13-15H2,1-3H3/t19-,20-,21-,23+,24-,25-,27-,28+/m0/s1
Molecular Formula
C28H35FO7
HBD / HBA
1 / 8
Rotatable Bonds
4
Heavy Atoms
36
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
A high-potency topical corticosteroid that reduces skin inflammation, redness, and itching by suppressing immune mediators and stabilizing cell membranes in the skin. It is used for inflammatory skin conditions such as psoriasis, eczema, and contact dermatitis that have not responded adequately to lower-potency steroids.
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
Yes, Amcinonide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200732. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 443958. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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