Anagliptin
A DPP-4 inhibitor that prevents the breakdown of hormones called incretins, which stimulate insulin release after eating, helping to lower blood sugar in type 2 diabetes. It is used as part of a comprehensive diabetes management plan.
Molecular Weight
383.4000 g/mol
LogP
0.00
TPSA
115.00 Ų
Lipinski RO5
Pass
Therapeutic Areas
Mechanism of Action
Inhibits dipeptidyl peptidase-4, the enzyme that rapidly degrades incretin hormones (GLP-1 and GIP). This prolongs incretin activity, stimulating glucose-dependent insulin secretion and suppressing glucagon release.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits dipeptidyl peptidase-4, the enzyme that rapidly degrades incretin hormones (GLP-1 and GIP). This prolongs incretin activity, stimulating glucose-dependent insulin secretion and suppressing glucagon release.
2D Structure
Cite this structure
Embed this structure
SMILES
Cc1cc2ncc(C(=O)NCC(C)(C)NCC(=O)N3CCC[C@H]3C#N)cn2n1
InChI
InChI=1S/C19H25N7O2/c1-13-7-16-21-9-14(11-26(16)24-13)18(28)22-12-19(2,3)23-10-17(27)25-6-4-5-15(25)8-20/h7,9,11,15,23H,4-6,10,12H2,1-3H3,(H,22,28)/t15-/m0/s1
Molecular Formula
C19H25N7O2
HBD / HBA
2 / 6
Rotatable Bonds
6
Heavy Atoms
28
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
A DPP-4 inhibitor that prevents the breakdown of hormones called incretins, which stimulate insulin release after eating, helping to lower blood sugar in type 2 diabetes. It is used as part of a comprehensive diabetes management plan.
Inhibits dipeptidyl peptidase-4, the enzyme that rapidly degrades incretin hormones (GLP-1 and GIP). This prolongs incretin activity, stimulating glucose-dependent insulin secretion and suppressing glucagon release.
Yes, Anagliptin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1929396. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 44513473. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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