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Bictegravir Sodium

CHEMBL3989867 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
471.4 g/mol
LogP
—
Phase
4

The sodium salt form of bictegravir, an HIV integrase inhibitor used in combination antiretroviral therapy for HIV-1 infection. It is part of a once-daily fixed-dose combination that also includes two other antiretroviral agents. It has a high barrier to resistance development.

Molecular Weight

471.4000 g/mol

TPSA

102.00 Ų

Therapeutic Areas

Heart Failure HIV/AIDS Obesity Rheumatoid Arthritis Tuberculosis

Mechanism of Action

Inhibits viral integrase, preventing the insertion of viral DNA into the host cell genome and blocking viral replication.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanism

Inhibits viral integrase, preventing the insertion of viral DNA into the host cell genome and blocking viral replication.

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
O=C(NCc1c(F)cc(F)cc1F)c1cn2c(c([O-])c1=O)C(=O)N1[C@H]3CC[C@H](C3)O[C@@H]1C2.[Na+]

                

                

                
                

                    
InChI

                    
InChI=1S/C21H18F3N3O5.Na/c22-9-3-14(23)12(15(24)4-9)6-25-20(30)13-7-26-8-16-27(10-1-2-11(5-10)32-16)21(31)17(26)19(29)18(13)28;/h3-4,7,10-11,16,29H,1-2,5-6,8H2,(H,25,30);/q;+1/p-1/t10-,11+,16+;/m0./s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C21H17F3N3NaO5

                    

                    
                    

                        
HBD / HBA

                        
1 / 9

                    

                    
                    

                        
Rotatable Bonds

                        
3

                    

                    
                    
                    

                        
Heavy Atoms

                        
33

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
The sodium salt form of bictegravir, an HIV integrase inhibitor used in combination antiretroviral therapy for HIV-1 infection. It is part of a once-daily fixed-dose combination that also includes two other antiretroviral agents. It has a high barrier to resistance development.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits viral integrase, preventing the insertion of viral DNA into the host cell genome and blocking viral replication.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Bictegravir Sodium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL3989867.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 102593990.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.