Bitolterol
A beta-2 adrenergic agonist bronchodilator that was used to treat and prevent bronchospasm in asthma and chronic obstructive pulmonary disease. It is a prodrug that is converted to the active compound colterol in the body. It was withdrawn from the market and replaced by other bronchodilators.
Molecular Weight
461.5000 g/mol
LogP
5.20
TPSA
84.90 Ų
Lipinski RO5
Pass
Mechanism of Action
Activates beta-2 adrenergic receptors on bronchial smooth muscle, stimulating adenylyl cyclase and increasing intracellular cAMP. This relaxes airway smooth muscle and produces bronchodilation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Activates beta-2 adrenergic receptors on bronchial smooth muscle, stimulating adenylyl cyclase and increasing intracellular cAMP. This relaxes airway smooth muscle and produces bronchodilation.
2D Structure
Cite this structure
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SMILES
Cc1ccc(C(=O)Oc2ccc(C(O)CNC(C)(C)C)cc2OC(=O)c2ccc(C)cc2)cc1
InChI
InChI=1S/C28H31NO5/c1-18-6-10-20(11-7-18)26(31)33-24-15-14-22(23(30)17-29-28(3,4)5)16-25(24)34-27(32)21-12-8-19(2)9-13-21/h6-16,23,29-30H,17H2,1-5H3
Molecular Formula
C28H31NO5
HBD / HBA
2 / 6
Rotatable Bonds
10
Heavy Atoms
34
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
A beta-2 adrenergic agonist bronchodilator that was used to treat and prevent bronchospasm in asthma and chronic obstructive pulmonary disease. It is a prodrug that is converted to the active compound colterol in the body. It was withdrawn from the market and replaced by other bronchodilators.
Activates beta-2 adrenergic receptors on bronchial smooth muscle, stimulating adenylyl cyclase and increasing intracellular cAMP. This relaxes airway smooth muscle and produces bronchodilation.
Yes, Bitolterol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201295. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 35330. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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